Antibacterial Activity of Membrane-Permeabilizing Bactericidal Cyclodextrin Derivatives
Hatsuo Yamamura, Tatsuya Hagiwara, Yuma Hayashi, Kayo Osawa, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Ayumi Sumino, Hayato Yamashita, Ryo Jinno, Masayuki Abe, Atsushi Miyagawa
Abstract
. Several lines of evidence showed that these agents disrupt bacterial membranes, leading to rapid bacterial cell death. The resulting membrane perturbation was directly visualized using high-speed atomic force microscopy imaging. In Gram-negative bacteria, the membrane-permeabilizing action of these derivatives allowed the entry of co-treated traditional antibiotics, which were then active against these bacteria.
Topics & Concepts
BacteriaMembraneAntibacterial activityChemistryBacterial cell structureCyclodextrinAntimicrobialGram-negative bacteriaPeptideCell membraneAntimicrobial peptidesBiochemistryCombinatorial chemistryMicrobiologyEscherichia coliBiologyOrganic chemistryGeneGeneticsAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationBacteriophages and microbial interactions