<i>In Vitro</i> Antimicrobial Evaluation, Single-Point Resistance Study, and Radiosterilization of Novel Pyrazole Incorporating Thiazol-4-one/Thiophene Derivatives as Dual DNA Gyrase and DHFR Inhibitors against MDR Pathogens
Hazem Ali Mohamed, Yousry A. Ammar, Gameel A. M. Elhagali, Hassan A. Eyada, Dina S. Aboul‐Magd, Ahmed Ragab
Abstract
and enhancing its antimicrobial activity. Finally, molecular docking simulation of the most promising derivatives exhibited good binding energy with different interactions.
Topics & Concepts
DNA gyraseMinimum inhibitory concentrationAntimicrobialPyrazoleMinimum bactericidal concentrationStaphylococcus epidermidisChemistryCiprofloxacinTopoisomerase IVStaphylococcus aureusIC50MicrobiologyIn vitroStereochemistryBacteriaBiologyBiochemistryEscherichia coliAntibioticsOrganic chemistryGeneticsGeneSynthesis and biological activitySynthesis and Biological EvaluationCancer therapeutics and mechanisms