Covalent Grafting of Antimicrobial Peptides onto Microcrystalline Cellulose
Paola Sperandeo, Fabrizio Bosco, Francesca Clerici, Alessandra Polissi, Maria Luisa Gelmi, Alessandra Romanelli
Abstract
cultures show that the cellulose conjugated to the peptides lasioglossin-III and TBKKG6A causes a significant reduction in the concentration of viable cells as compared to unmodified cellulose. In conclusion, antimicrobial peptides bound to cellulose through a covalent bond retain their activity and therefore have the potential to be used as active ingredients in antimicrobial materials.
Topics & Concepts
CellulosePeptideCovalent bondChemistryMicrocrystalline celluloseAntimicrobialCysteineCombinatorial chemistryAntimicrobial peptidesThioesterConjugated systemBacterial celluloseOrganic chemistryBiochemistryEnzymePolymerAntimicrobial Peptides and ActivitiesPolydiacetylene-based materials and applicationsBiopolymer Synthesis and Applications