Clinical controversy: methodology and indications of cardioneuroablation for reflex syncope
Michele Brignole, Tolga Aksu, Leonardo Calò, Philippe Debruyne, Jean‐Claude Deharo, Alessandra Fanciulli, Artur Fedorowski, Piotr Kułakowski, Carlos A. Morillo, Angel Moya, Brian Olshansky, Roman Piotrowski, Sebastian Stec, Dan Wichterle
Abstract
Observational studies and a recent randomized controlled trial have provided some evidence that cardioneuroablation (CNA) may prevent syncope recurrence in patients affected by cardioinhibitory reflex syncope during the first 2 years following the procedure. Nevertheless, many issues concerning clinical indications, methodology, and long-term results remain unresolved. These issues constitute the background of this manuscript in which pioneers in CNA and experts in syncope debated critical aspects aimed at finding agreement or, if not possible, that highlighting the controversies could be addressed in future studies.