Advances in diagnosing mild cognitive impairment and Alzheimer’s disease using 11C-PIB- PET/CT and common neuropsychological tests
Qing Zhao, Xinxin Du, Wenhong Chen, Ting Zhang, Zhuo Xu
Abstract
Alzheimer’s disease (AD) is a critical health issue worldwide that has a negative impact on patients’ quality of life, as well as on caregivers, society, and the environment. Positron emission tomography (PET)/computed tomography (CT) and neuropsychological scales can be used to identify AD and mild cognitive impairment (MCI) early, provide a differential diagnosis, and offer early therapies to impede the course of the illness. However, there are few reports of large-scale 11 C-PIB-PET/CT investigations that focus on the pathology of AD and MCI. Therefore, further research is needed to determine how neuropsychological test scales and PET/CT measurements of disease progression interact.
Topics & Concepts
NeuropsychologyPositron emission tomographyCognitive impairmentMedicineNeuropsychological assessmentNeuropsychological testNeuropsychological testingDiseaseCognitionPsychologyAlzheimer's diseaseQuality of life (healthcare)PsychiatryRadiologyPathologyNursingDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies