<i>η</i><sup>6</sup>‐Arene CH−O Interaction Directed Dynamic Kinetic Resolution – Asymmetric Transfer Hydrogenation (DKR‐ATH) of α‐Keto/enol‐Lactams
Zhonghua Luo, Guodong Sun, Shuming Wu, Yong Chen, Yicao Lin, Lei Zhang, Zhongqing Wang
Abstract
Abstract A dynamic kinetic resolution – asymmetric transfer hydrogenation (DKR‐ATH) methodology of α‐keto/enol‐lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by η 6 ‐arene CH−O interaction. The efficient approach can be applied to a wide range of substrates including non‐aryl ones which would be difficult to prepare by other asymmetric reduction methods. magnified image
Topics & Concepts
ChemistryKinetic resolutionEnolTransfer hydrogenationArylCatalysisAsymmetric hydrogenationCombinatorial chemistryStereochemistryComputational chemistryEnantioselective synthesisOrganic chemistryRutheniumAlkylAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisCarbon dioxide utilization in catalysis