Covalent sortase A inhibitor ML346 prevents <i>Staphylococcus aureus</i> infection of <i>Galleria mellonella</i>
Xiang‐Na Guan, Tao Zhang, Teng Yang, Ze Dong, Song Yang, Lefu Lan, Jianhua Gan, Cai‐Guang Yang
Abstract
Covalent sortase A inhibitor ML346 prevents Galleria mellonella from Staphylococcus aureus infection by interfering in the transpeptidation activity of sortase A for anchoring surface proteins into staphylococci envelope.
Topics & Concepts
Sortase AStaphylococcus aureusMicrobiologyGalleria mellonellaVirulenceSortaseStreptococcus pyogenesPeptidoglycanBiologyChemistryBiochemistryBacteriaCell wallGeneticsGeneBiochemical and Structural CharacterizationPhytoplasmas and Hemiptera pathogensToxin Mechanisms and Immunotoxins