Functional subgroups of cochlear inner hair cell ribbon synapses differently modulate their EPSC properties in response to stimulation
Mamiko Niwa, Eric D. Young, Elisabeth Glowatzki, Anthony J. Ricci
Abstract
Data presented here provide the first direct functional evidence of late synaptic maturation of the hair cell- spiral ganglion neuron synapse, where pillar synapses mature after postnatal day 20. Data identify a presynaptic difference in release during stimulation. This difference may in part drive afferent firing properties.
Topics & Concepts
SynapseExcitatory postsynaptic potentialRibbon synapseNeurosciencePostsynaptic potentialSpiral ganglionStimulationPostsynaptic CurrentNeurotransmissionHair cellChemistryInhibitory postsynaptic potentialBiologyCochleaSynaptic vesicleReceptorVesicleBiochemistryMembraneHearing, Cochlea, Tinnitus, GeneticsHearing Loss and RehabilitationAcoustic Wave Phenomena Research