Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function
Jian Tan, Duan Ni, Jibran A. Wali, Darren Anthony Cox, Gabriela Veronica Pinget, Jemma Taitz, C. Daïen, Alistair M. Senior, Mark Read, Stephen J. Simpson, Nicholas J. C. King, Laurence Macia
Abstract
and reduced B cell apoptosis in early development via mTOR activation, independently of interleukin-7. Ours is the first comprehensive study showing the impact of macronutrients on B cell development and function. It shows the quantitative and qualitative interplay between dietary carbohydrate and B cells and argues for dietary modulation in B cell-targeting strategies.
Topics & Concepts
B cellLymphopoiesisBiologyCarbohydrateMesenteric lymph nodesSpleenEndocrinologyInternal medicineBiochemistryImmunologyAntibodyStem cellCell biologyHaematopoiesisMedicineImmune Cell Function and InteractionImmune cells in cancerNF-κB Signaling Pathways