Self-luminescent photodynamic therapy using breast cancer targeted proteins
Eun Hye Kim, Sangwoo Park, Yun Kyu Kim, Minwoo Moon, Jeongwon Park, Kyung Jin Lee, Seongsoo Lee, Young‐Pil Kim
Abstract
as a substrate for luciferase without external light irradiation, Luc-RGP fused with a small lead peptide-induced breast cancer cell death through the generation of BL-sensitive ROS in the plasma membrane. Even with extremely low light energy, BLiP-PDT exhibited targeted effects in primary breast cancer cells from patients and in in vivo tumor xenograft mouse models. These findings suggest that BLiP-PDT is immediately useful as a promising theranostic approach against various cancers.
Topics & Concepts
Photodynamic therapyBreast cancerCancerMedicineCancer researchBioinformaticsComputational biologyBiologyChemistryInternal medicineOrganic chemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsbioluminescence and chemiluminescence research