A review on the chemistry and pharmacological properties of benzodiazepine motifs in drug design
Olayinka O. Tolu-Bolaji, Samuel O. Sojinu, Adebola P. Okedere, Olayinka O. Ajani
Abstract
Benzodiazepines are an important class of heterocyclic compounds in organic \nchemistry. They are known for their diverse physicochemical and biological properties. \nSome benzodiazepine derivates are well-known drugs with diverse and strong \npharmacophoric moiety. An immense number of pharmacological research on \nbenzodiazepine heterocycles and their derivatives have recently been conducted to \nexplore its numerous pharmacological potentials as better therapeutic candidates for \nthe treatment of various disorders, benzodiazepines, however, are one of the main \nsources of interest for many medicinal chemists. Researchers are drawn to the \nbenzodiazepine nucleus for the synthesis of new drugs because of its potent \npharmacophoric moiety and ring shape. Due to the emergence of new pathogenic \nstrains’ resistance to the presently available drugs, there has been a constant demand \nfor more effective and selective drugs. Benzodiazepine moiety has all the desired \nqualities for selective drug candidates used as useful therapeutic agents. Given the importance of benzodiazepine moiety, the current review aims to assess \nbenzodiazepine syntheses as well as their pharmacological properties for potential \nmolecular targets in therapeutic development.