Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell–cold solid tumors
Brian Belmontes, Deepali V. Sawant, Wendy Zhong, Hong Tan, Anupurna M. Kaul, Famke Aeffner, Sarah A. O’Brien, Matthew G. H. Chun, Rajkumar Noubade, Jason S. Eng, Hayley Ma, Markus Muenz, Peng Li, Benjamin M. Alba, Melissa Thomas, Kevin D. Cook, Xiaoting Wang, Jason DeVoss, Jackson G. Egen, Olivier Nolan-Stevaux
Abstract
T cells, rather than their recruitment from circulation. Our findings highlight the relative contributions of baseline T cell infiltration, local T cell proliferation, and peripheral T cell trafficking for BiTE molecule-mediated efficacy, identify combination strategies capable of overcoming resistance to BiTE therapy, and have clinical relevance for the development of BiTE and other T cell engager therapies.
Topics & Concepts
T cellImmunotherapyCancer researchCD8MedicineCancer immunotherapyImmune systemImmunologyCytotoxic T cellBiologyIn vitroBiochemistryCAR-T cell therapy researchImmune Cell Function and InteractionMonoclonal and Polyclonal Antibodies Research