Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology
Jürgen Lassak, Alina Sieber, Michael Hellwig
Abstract
Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical diversity of post-translational modifications. This results in a wide range of possibilities to influence protein function and hence modulate cellular physiology. Concomitantly, lysine derivatives form a metabolic reservoir that can confer selective advantages to those organisms that can utilize it. In this review, we provide examples of selected lysine modifications and describe their role in bacterial physiology.
Topics & Concepts
LysineAmino acidFunctional diversityPosttranslational modificationComparative physiologyBiochemistryFunction (biology)ChemistryCell physiologyBiologyComputational biologyPhysiologyCell biologyEcologyCellEnzymeEnzyme Structure and FunctionRNA and protein synthesis mechanismsAntimicrobial Peptides and Activities