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Mesenchymal stem cells-derived HIF-1α-overexpressed extracellular vesicles ameliorate hypoxia-induced pancreatic β cell apoptosis and senescence through activating YTHDF1-mediated protective autophagy

Jiali Fang, Zheng Chen, Xingqiang Lai, Wei Yin, Yuhe Guo, Weiting Zhang, Junjie Ma, Guanghui Li, Lei Zhang

2022Bioorganic Chemistry29 citationsDOI

Topics & Concepts

AutophagyCell biologyMesenchymal stem cellDownregulation and upregulationATG5TransplantationApoptosisViability assayProgrammed cell deathCancer researchSenescenceCellPancreatic isletsHypoxia (environmental)ChemistryIsletBiologyEndocrinologyMedicineInternal medicineInsulinBiochemistryGeneOrganic chemistryOxygenRNA modifications and cancerMicroRNA in disease regulationAutophagy in Disease and Therapy
Mesenchymal stem cells-derived HIF-1α-overexpressed extracellular vesicles ameliorate hypoxia-induced pancreatic β cell apoptosis and senescence through activating YTHDF1-mediated protective autophagy | Litcius