A case series of acne following Janus kinase inhibitors in patients with atopic dermatitis
Sang-doo Lee, Hye‐Jin Ahn, Min Kyung Shin
Abstract
The Janus kinase (JAK) family is a group of tyrosine kinases that is coupled to the cytoplasmic signal transducer of transcription (STAT) factors and mediates cytokine signaling. Four different JAKs, namely JAK1, JAK2, JAK3, and tyrosine kinase, harbor different cytokine receptors relevant to the pathophysiology of many inflammatory skin diseases, including atopic dermatitis (AD), psoriasis, and alopecia areata. Therefore, several JAK inhibitors have reached the market or are still in clinical development as a novel therapeutic option for inflammatory diseases.
Topics & Concepts
Janus kinaseMedicineJanus kinase 1Alopecia areataTyrosine kinase 2Atopic dermatitisJAK-STAT signaling pathwayTyrosine kinaseCytokine receptorPsoriasisstatAcneCancer researchCytokineSignal transductionDermatologyImmunologyReceptorSTAT3Internal medicinePlatelet-derived growth factor receptorBiologyCell biologyGrowth factorDermatology and Skin DiseasesPharmacological Effects of Natural CompoundsUrticaria and Related Conditions