Protective effect of vitexin against high fat-induced vascular endothelial inflammation through inhibiting trimethylamine<i>N</i>-oxide-mediated RNA m6A modification
Wenwen Li, Zeyuan Deng, Shuang Xiao, Qian Du, Mengru Zhang, Hailing Song, Caidong Zhao, Liufeng Zheng
Abstract
mouse experiments. Specifically, TMAO increased m6A levels and inflammation, while vitexin inhibited TMAO-mediated m6A modification, exhibiting anti-inflammatory effects. In conclusion, this study demonstrates the protective role of vitexin against HFD-induced vascular inflammation by inhibiting TMAO-mediated RNA m6A modification, laying the foundation for the development of functional foods.
Topics & Concepts
Trimethylamine N-oxideInflammationChemistryVitexinNitric oxidePharmacologyTrimethylamineBiochemistryMedicineEndocrinologyInternal medicineAntioxidantFlavonoidRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing