Combined repetitive inhalant endotoxin and collagen-induced arthritis drive inflammatory lung disease and arthritis severity in a testosterone-dependent manner
Jill A. Poole, Geoffrey M. Thiele, Elizabeth Ramler, Amy Nelson, Michael J. Duryee, Aaron Schwab, Angela Gleason, Carlos D. Hunter, Rohit Gaurav, Todd A. Wyatt, Bryant R. England, Ted R. Mikuls
2023American Journal of Physiology-Lung Cellular and Molecular Physiology14 citationsDOIOpen Access PDF
Abstract
Our study shows that testosterone acts as a key immunomodulatory hormone contributing to critical features of rheumatoid arthritis (RA)-associated lung disease in the setting of airborne endotoxin (lipopolysaccharide; LPS) exposures and concomitant arthritis induction in mice. The exaggerated airway inflammation observed following combined exposures in male mice was accompanied by increases in profibrotic mediators, netosis, and increased expression of lung autoantigens, all relevant to the pathogenesis of lung disease in arthritis.
Topics & Concepts
Rheumatoid arthritisMedicineArthritisLipopolysaccharidePathogenesisImmunologyInflammationLungInflammatory arthritisTestosterone (patch)Internal medicineAsthma and respiratory diseasesIL-33, ST2, and ILC PathwaysAllergic Rhinitis and Sensitization