Potassium <i>tert</i>-Butoxide Promoted Synthesis of Dihydroquinazolinones
Tridev Ghosh, Indradip Mandal, Soumya Jyoti Basak, Jyotirmayee Dash
Abstract
We herein report an efficient synthetic protocol to access heterocyclic dihydroquinazolinones by a transition-metal-free process, involving the reaction of 2-aminobenzonitriles with aldehydes in the presence of KOtBu. The method is compatible with aromatic ketones providing 2,2-disubstituted dihydroquinazolinones in high yields. This reaction proceeds feasibly at room temperature and features a broad substrate scope and tolerance to a range of functional groups. The mechanism follows a radical pathway.
Topics & Concepts
ChemistryCombinatorial chemistrySubstrate (aquarium)Scope (computer science)Functional groupPotassiumOrganic chemistryProgramming languageGeologyComputer sciencePolymerOceanographyQuinazolinone synthesis and applicationsAdvanced Synthetic Organic ChemistryMicrowave-Assisted Synthesis and Applications