Identification of Novel Rotihibin Analogues in <i>Streptomyces scabies</i> , Including Discovery of Its Biosynthetic Gene Cluster
Sören Planckaert, Benoit Deflandre, Anne-Mare de Vries, Maarten Ameye, José C. Martins, Kris Audenaert, Sébastien Rigali, Bart Devreese
Abstract
strains, both pathogenic and nonpathogenic species, raising new questions about the actual function of this lipopeptide. The discovery of a module in the nonribosomal peptide synthetase (NRPS) that incorporates the unusual citrulline residue may improve the prediction of peptides encoded by cryptic NRPS gene clusters.
Topics & Concepts
Gene clusterBiologyStreptomycesPolyketideBiosynthesisGeneStreptomyces avermitilisBiochemistryNonribosomal peptideGeneticsBacteriaPlant Disease Resistance and GeneticsPlant-Microbe Interactions and ImmunityPlant Pathogens and Resistance