Cytokines of the IL‐17 family in psoriasis
Felix Lauffer, Kilian Eyerich, Wolf‐Henning Boehncke, Khusru Asadullah, Stefan Beissert, Kamran Ghoreschi, Michael P. Schön
Abstract
Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL-17 family are of particular importance. In addition to IL-17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL-17 family also have a proinflammatory effect. This review provides an up-to-date overview of the immunopathogenesis of psoriasis with regard to the six IL-17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.
Topics & Concepts
PsoriasisProinflammatory cytokineImmunologyPathogenesisImmune systemInterleukin 17MedicineInflammationPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and InteractionsDermatology and Skin Diseases