VDAC1 oligomerization-mediated mtDNA release under sublethal oxidative stress: A novel inflammatory mechanism in vitiligo
Rongyin Gao, Duo Meng, Zhilin Zhao, Hui Xue, Nan Hu, Peiwen Jiang, Wenhao Yu, Wenhui Xu, Chuanwei Yin, Huansha Zhang, Jinpeng Lv
Topics & Concepts
VDAC1VitiligoVoltage-dependent anion channelOxidative stressSOD2Cell biologyMitochondrial ROSMitochondrionBiologyGene knockdownMitochondrial permeability transition poreImmune systemChemistryMitochondrial DNACytokineInnate immune systemProgrammed cell deathApoptosisReactive oxygen speciesImmunologyDNA damageTumor necrosis factor alphaTranscription factorInflammationCancer researchPharmacologyOxidative phosphorylationCytosolMolecular biologyCREBInterferonNecroptosismelanin and skin pigmentationinterferon and immune responsesHerpesvirus Infections and Treatments