Bactericidal Effect of Cecropin A Fused Endolysin on Drug-Resistant Gram-Negative Pathogens
Jeonghyun Lim, Juyeon Hong, Yongwon Jung, Jae‐Won Ha, Hwan Kim, Heejoon Myung, Mi‐Ryoung Song
Abstract
Development of novel antibiotics relies on the finding of natural compounds and synthetic modification of them but the number of new antibiotics gradually decreased due to a shortage of mined natural compounds Given this situation, the rapid emergence and spread of resistance to antibiotics resulting from overuse and misuse in both livestock and medical fields have become a major threat to public health in recent years Moreover, multi-drug resistant, extensively drug-resistant and pandrug-resistant strains are quickly rising, which highlights the urgent need for new treatment options for infectious diseases
Topics & Concepts
MicrobiologyAcinetobacter baumanniiLysinBiologyLytic cyclePeptidoglycanAntimicrobialGalleria mellonellaEnterobacter cloacaePseudomonas aeruginosaPhage therapyEscherichia coliBacteriophageBacteriaKlebsiella pneumoniaeVirologyVirulenceBiochemistryVirusGeneGeneticsBacteriophages and microbial interactionsAntimicrobial Peptides and ActivitiesGenomics and Phylogenetic Studies