Microglial autophagy in cerebrovascular diseases
Man Chen, Hang Zhang, Yun‐Hui Chu, Yue Tang, Xiao‐Wei Pang, Chuan Qin, Dai‐Shi Tian
Abstract
Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of microglia. Recently some evidence suggests that microglial autophagy is closely associated with brain function in both ischemic stroke and hemorrhagic stroke. Herein, we will discuss the interaction between autophagy and other biological processes in microglia under physiological and pathological conditions and highlight the interaction between microglial metabolism and autophagy. In the end, we focus on the effect of microglial autophagy in cerebrovascular diseases.
Topics & Concepts
AutophagyMicrogliaNeuroscienceHomeostasisInnate immune systemStroke (engine)Central nervous systemImmune systemPathologicalBiologyNeuroinflammationInflammationMedicineImmunologyCell biologyPathologyApoptosisMechanical engineeringEngineeringBiochemistryNeuroinflammation and Neurodegeneration MechanismsAutophagy in Disease and TherapyExtracellular vesicles in disease