Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function
Ashlyn C. Harmon, Alexandra Noël, Subramanian Balamurugan, Zakia Perveen, Merilyn H. Jennings, Yifan Chen, Arthur Penn, Kelsey Legendre, Daniel B. Paulsen, Kurt J. Varner, Tammy R. Dugas
Abstract
Particulate matter (PM) resulting from the combustion of organic matter is known to contribute to cardiopulmonary disease. Despite hypotheses that cardiovascular dysfunction occurring after PM exposures is secondary to lung or systemic inflammation, these studies investigating exposures to PM-containing environmentally persistent free radicals (EPFRs) demonstrate that cardiovascular dysfunction precedes pulmonary inflammation. The cardiopulmonary health consequences of EPFRs have yet to be thoroughly evaluated, especially in healthy, adult mice. Our data suggest the vasculature as a direct target of PM exposure, and our studies aimed to elucidate the mechanisms contributing to EPFR-induced vascular dysfunction.