Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1,3,4-oxadiazole moieties as potential thymidylate synthase inhibitors
Abdulraheem S. A. Almalki, Syed Nazreen, Serag Eldin I. Elbehairi, Mohammad Asad, Ali A. Shati, Mohammad Y. Alfaifi, A. Alhadhrami, Ahmed A. Elhenawy, Ali Q. Alorabi, Abdullah M. Asiri, Mohammad Mahboob Alam
Abstract
Compounds 10 and 14 arrest the cell cycle at the G1 phase and induce apoptosis without any necrosis in MDA-MB-231 cells.
Topics & Concepts
ChemistryBenzimidazoleThymidylate synthaseOxadiazoleDocking (animal)ApoptosisStereochemistryCell cycleCell cycle checkpointCombinatorial chemistryBiochemistryOrganic chemistryMedicineNursingSurgeryChemotherapyFluorouracilSynthesis and biological activityBiochemical and Molecular ResearchQuinazolinone synthesis and applications