Synthesis of <i>S</i> -alkyl phosphorothioates/phosphorodithioates <i>via</i> ring-opening reaction of sulfonium salts with S <sub>8</sub> , <i>H</i> -phosphonates or P <sub>4</sub> S <sub>10</sub> , and alcohols
Li‐Hua Yang, Lin Chen, Bei Li, Yuan-Xin Jin, Yun Liu, Sha Peng, Long‐Yong Xie
Abstract
A simple and practical method for the synthesis of S -alkyl phosphorothioates/phosphorodithioates through the three-component reaction of cyclic sulfonium salts with S 8 , H -phosphonates, or P 4 S 10 , and alcohols was readily developed.
Topics & Concepts
SulfoniumChemistryAlkylRing (chemistry)Medicinal chemistryOrganic chemistrySalt (chemistry)Sulfur-Based Synthesis TechniquesSynthesis and Reactivity of Sulfur-Containing CompoundsOrganophosphorus compounds synthesis