Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus
Xinghui Li, Yandi Wu, Jingjing Zhao, Haiping Wang, Jing Tan, Ming Yang, Yuanlong Li, Shijie Deng, Saifei Gao, Hui Li, Zhenyu Yang, Fengmin Yang, Jian‐xing Ma, Jianding Cheng, Weibin Cai
Abstract
: Myocardial injury in obese and non-obese T2DM may represent two different types of complications. Obese T2DM individuals, compared to non-obese individuals, are more prone to develop cardiac systolic dysfunction due to severe and persistent myocardial lipotoxicity. Additionally, anti-oxidative dysfunction may be a key factor leading to myocardial injury in non-obese T2DM.
Topics & Concepts
Oxidative stressEnergy metabolismDiabetes mellitusInternal medicineType 2 Diabetes MellitusObesityEndocrinologyMedicineType 2 diabetesOxidative phosphorylationBioinformaticsBiologyBiochemistryAdipose Tissue and MetabolismCardiovascular Function and Risk FactorsCardiovascular and exercise physiology