Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation
Liridona Useini, Marija Mojić, Markus Laube, Peter Lönnecke, Jonas Dahme, Menyhárt B. Sárosi, Sanja Mijatović, Danijela Maksimović‐Ivanić, Jens Pietzsch, Evamarie Hey‐Hawkins
Abstract
-carborane derivatives were synthesized in three steps: halogenation of the respective cluster, followed by a Pd-catalyzed B-N coupling and hydrolysis of the nitrile derivatives under acidic conditions. The COX inhibitory activity and cytotoxicity for different cancer cell lines revealed that the carborane analogues have stronger antitumor potential compared to their parent organic compound.
Topics & Concepts
Mefenamic acidChemistryPharmacologyCytotoxicityCyclooxygenaseNitrileDrugProstaglandin E2StereochemistryCombinatorial chemistryBiochemistryOrganic chemistryMedicineEnzymeChromatographyInternal medicineIn vitroBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsBone health and treatments