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Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity

Pablo Garrido-García, Irene Quirós, Paula Milán-Rois, Silvia Ortega‐Gutiérrez, Mar Martín‐Fontecha, Luis A. Campos, Álvaro Somoza, Israel Fernández, Thomas Rigotti, Mariola Tortosa

2025Nature Chemistry31 citationsDOI

Topics & Concepts

ChemistryEnantioselective synthesisBicyclic moleculeBenzenePhotocatalysisBenzene derivativesOrganic chemistryCombinatorial chemistryStereochemistryChemical synthesisCatalysisBiochemistryIn vitroRadical Photochemical ReactionsOrganic Chemistry Cycloaddition ReactionsPhotochromic and Fluorescence Chemistry
Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity | Litcius