A CO-mediated photothermal therapy to kill drug-resistant bacteria and minimize thermal injury for infected diabetic wound healing
Xin Jin, Zelin Ou, Guowei Zhang, Rong Shi, Jumin Yang, Wenguang Liu, Gaoxing Luo, Jun Deng, Wei Wang
Abstract
the WNT and PI3K-Akt pathways to reduce thermal injury, especially with a laser with a high-power density. The CO-mediated PTT unified the bacterial killing with tissue protection, which offers a promising concept to improve PTT efficiency and minimize the side-effects of PTT when treating infected skin wounds.
Topics & Concepts
Photothermal therapyBacteriaChemistryHsp90Protein kinase BDownregulation and upregulationWound healingMicrobiologyHeat shock proteinPharmacologyBiochemistryMedicineSignal transductionBiologyNanotechnologyMaterials scienceImmunologyGeneGeneticsHeme Oxygenase-1 and Carbon MonoxideBurn Injury Management and OutcomesThermal Regulation in Medicine