Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells
Vanessa Zurli, Tommaso Montecchi, Raphael Heilig, Isabel Poschke, Michael Volkmar, Giuliana Wimmer, Gioia Boncompagni, Gabriele Turacchio, Mario Milco D’Elios, Giuseppe Campoccia, Nicoletta Resta, Rienk Offringa, Román Fischer, Oreste Acuto, Cosima T. Baldari, Anna Kabanova
Abstract
T cells and strengthen the rationale to choose CD2 and AMPK as therapeutic targets to enhance CTL activity.
Topics & Concepts
Lytic cycleAMPKPhosphoproteomicsCytotoxic T cellCell biologyGranule (geology)ChemistryCytotoxicityPhosphorylationBiologyProtein kinase AImmunologyIn vitroBiochemistryProtein phosphorylationPaleontologyVirusT-cell and B-cell ImmunologyImmune Cell Function and InteractionCalcium signaling and nucleotide metabolism