Intracellular Transposition of Mobile Genetic Elements Associated with the Colistin Resistance Gene <i>mcr-1</i>
Richard N. Goodman, Supathep Tansirichaiya, Michael S. M. Brouwer, Adam P. Roberts
Abstract
By analyzing the intracellular transfer of clinically relevant transposons, we can understand the dissemination and evolution of drug resistance conferring mobile genetic elements (MGEs) once a plasmid enters a cell following conjugation. This knowledge will help further our understanding of how these important genes move through bacterial populations. Utilizing the pBACpAK entrapment vector has allowed us to determine the mobility of the novel mcr-1 -containing transposon Tn 7511 .
Topics & Concepts
Transposable elementBiologyTransposition (logic)PlasmidGeneticsMobile genetic elementsRepliconInsertion sequenceTransposaseHorizontal gene transferGenomeGeneTn10LinguisticsPhilosophyAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyDrug Transport and Resistance Mechanisms