Anti‐phytopathogenic activity and the mechanisms of phthalides from <i>Angelica sinensis</i> (Oliv.) Diels
Yan‐Yan Ding, Yu Sun, Xiong‐Fei Luo, Shao‐Yong Zhang, Rui Wang, Zhigang Yang, Jingru Wang, Bao‐Qi Zhang, Zhijun Zhang, Yue Ma, Jun‐Xia An, Han Zhou, Ying‐Qian Liu
Abstract
BACKGROUND: The resistance of traditional chemical fungicides to plant pathogenic fungi and the threats to the safety of humans and the environment highlight an urgent need to find safe and efficient alternatives to chemical fungicides. Owing to the wide spectrum of antifungal activities, low persistence and nontoxicity to mammals and aquatic life, essential oils have considerable potential as low-risk pesticides. In this study, the essential oil and the main components of Angelica sinensis (Oliv.) Diels (Danggui) were extracted, analyzed by GC-MS, and evaluated for their antifungal activities against six plant pathogenic fungi. RESULTS: . The antifungal mechanistic studies revealed that 3-BPH induced the generation of endogenous ROS to cause lipid peroxidation of the cell membrane and inhibited the biosynthesis of ergosterol, thereby causing the cell membrane damaged to exert its fungicidal activity. Significantly, 3-BPH could reduce deoxynivalenol production compared to the control. CONCLUSION: This study demonstrated the potent fungicidal activity of natural phthalide compound 3-BPH and highlighted its potential as an alternative agent to control F. graminearum. © 2023 Society of Chemical Industry.