Designing a novel (R)-ω-transaminase for asymmetric synthesis of sitagliptin intermediate via motif swapping and semi-rational design
Fang-Ying Zhu, Mengyu Huang, Ken Zheng, Xiaojian Zhang, Xue Cai, Lianggang Huang, Zhi‐Qiang Liu, Yu‐Guo Zheng
Topics & Concepts
SitagliptinTransaminaseRational designChemistryMotif (music)StereochemistryCombinatorial chemistryMaterials scienceNanotechnologyBiochemistryEnzymeMedicineInternal medicinePhilosophyAestheticsMetforminInsulinEnzyme Catalysis and ImmobilizationCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins Research