Radiation injury and gut microbiota-based treatment
Weihong Wang, Bota Cui, Yongzhan Nie, Lijuan Sun, Faming Zhang
Abstract
The exposure to either medical sources or accidental radiation can cause varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and organs, yet effective treatments are currently limited. Accumulating evidence suggests gut microbiota are closely associated with the development and prevention of various RI. This article summarizes 10 common types of RI and their possible mechanisms. It also highlights the changes and potential microbiota-based treatments for RI, including probiotics, metabolites, and microbiota transplantation. Additionally, a 5P-Framework is proposed to provide a comprehensive strategy for managing RI.
Topics & Concepts
Gut floraRadiation injuryBiologyRadiation therapyDiseaseBioinformaticsImmunologyMedicineComputational biologyPathologyInternal medicineEffects of Radiation ExposureOral health in cancer treatmentHead and Neck Cancer Studies