Bioinspired exosome-SiO<sub>2</sub> nanohybrid therapeutic for rheumatoid arthritis treatment
Qicui Zhu, Ruofei Chen, Xueting Wu, Yuanyuan Zhou, Zexin Wang, Huaixuan Zhang, Haofang Zhu, Lingyun Sun, Zongwen Shuai
Abstract
The findings show that AE@SiO₂-MTX is a robust cell-free therapeutic platform for RA management. Synergy between the immunomodulatory properties of ADSC-EXO and MTX controlled release, this system can overcome the limitations of conventional cell therapies and achieve targeted anti-inflammatory and tissue-protective effects. This strategy offers a promising translational avenue for RA treatment.
Topics & Concepts
Rheumatoid arthritisExosomeNanotechnologyMedicineMicrovesiclesMaterials scienceChemistryImmunologymicroRNABiochemistryGeneRheumatoid Arthritis Research and TherapiesAdvanced Biosensing Techniques and ApplicationsExtracellular vesicles in disease