Detection of Pathogens and Regulation of Immunity by the Caenorhabditis elegans Nervous System
Yiyong Liu, Jingru Sun
Abstract
Although Caenorhabditis elegans has been used as a model host for studying host-pathogen interactions for more than 20 years, the mechanisms by which it identifies pathogens are not well understood. This is largely due to its lack of most known pattern recognition receptors (PRRs) that recognize pathogen-derived molecules.
Topics & Concepts
Caenorhabditis elegansBiologyPathogenImmunityHost (biology)Pattern recognition receptorCaenorhabditisImmune systemComputational biologyMicrobiologyImmunologyGeneticsGeneGenetics, Aging, and Longevity in Model OrganismsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders