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LUCS: a high-resolution nucleic acid sequencing tool for accurate long-read analysis of individual DNA molecules

Sofia Annis, Zoë Fleischmann, Robert Logan, Zachary Mullin-Bernstein, Melissa Franco, Josefin Saürich, Jonathan L. Tilly, Dori C. Woods, Konstantin Khrapko

2020Aging19 citationsDOIOpen Access PDF

Abstract

errors/nucleotide. Thus, LUCS represents a major step forward in DNA sequencing that offers high-throughput capacity and high-accuracy reads in studies of long DNA templates and nucleotide variants in heterogenous samples.

Topics & Concepts

Sanger sequencingComputational biologyDNA sequencingNucleic acidBiologyDNASequence (biology)Nucleic acid sequenceSequence analysisRNAGeneticsGeneRNA modifications and cancerRNA and protein synthesis mechanismsBacteriophages and microbial interactions
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