Probing Microenvironmental Acidity in Lyophilized Protein and Vaccine Formulations Using Solid-state NMR Spectroscopy
Mingyue Li, Sampada Koranne, Rui Fang, Xingyu Lu, Donna M. Williams, Eric J. Munson, Akhilesh Bhambhani, Yongchao Su
Topics & Concepts
HistidineChemistryNuclear magnetic resonance spectroscopyProtonationCrystallizationSolid-state nuclear magnetic resonanceTautomerChromatographyAmino acidBiochemistryOrganic chemistryNuclear magnetic resonancePhysicsIonAdvanced NMR Techniques and ApplicationsProtein purification and stabilityMuon and positron interactions and applications