Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota
Michelle Vang Mouritzen, Marija Petković, Katrine Qvist, Steen Seier Poulsen, Susana Alarico, Ermelindo C. Leal, Louise T. Dalgaard, Nuno Empadinhas, Eugénia Carvalho, Håvard Jenssen
Abstract
prevalence. LFcinB increased angiogenesis in diabetic mice (p < 0.01), but this was decreased in control mice (p < 0.05). LFcinB improved collagen deposition in both diabetic and control mice (p < 0.05). Both oxidative stress and the M1-to-M2 macrophage ratios were decreased in LFcinB-treated wounds of diabetic animals (p < 0.001 and p < 0.05, respectively) compared with saline, suggesting a downregulation of inflammation in diabetic wounds. In conclusion, LFcinB treatment demonstrated noticeable positive effects on diabetic wound healing.
Topics & Concepts
Immune systemWound healingMedicineInflammationImmunologyWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementPressure Ulcer Prevention and Management