GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production
Elaheh Mahootchi, Selina Cannon Homaei, Rune Kleppe, Ingeborg Winge, Tor‐Arne Hegvik, Roberto Pérez, Christian Totland, Floriana Mogavero, Anne Baumann, Jeffrey Glennon, Hrvoje Miletić, Petri Kursula, Jan Haavik
Abstract
locus with plasma levels of carnosine, subjective well-being, and muscle strength. Together, this shows the multifaceted and organ-specific roles of carnosine peptides and establishes Gadl1 knockout mice as a versatile model to explore carnosine biology and its therapeutic potential.
Topics & Concepts
CarnosineAnserineOxidative stressAlanineBiochemistryEnzymeChemistryAmino acidHistidineBiochemical effects in animalsStress Responses and CortisolBiochemical Acid Research Studies