Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates
Emil Uffelmann, Daniëlle Posthuma, Wouter J. Peyrot
Abstract
arising from : C. Gouveia et al.; Scientific Reports https://doi.org/10.1038/s41598-022-12391-2 (2022).
Topics & Concepts
Polygenic risk scoreGenome-wide association studyPhenotypeGeneticsFalse discovery rateBiologyGenetic associationMultiple comparisons problemBioinformaticsStatisticsGenotypeGeneSingle-nucleotide polymorphismMathematicsGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsBioinformatics and Genomic Networks