Esophageal extracellular matrix hydrogel mitigates metaplastic change in a dog model of Barrett’s esophagus
Juan Diego Naranjo, Lindsey T. Saldin, Eric Sobieski, Lina M. Quijano, Ryan C. Hill, Patrick G. Chan, Crisanto M. Torres, Jenna L. Dziki, Madeline C. Cramer, Yoojin C. Lee, Rohit Das, Anant K. Bajwa, Rania Nossair, Molly Klimak, Lucile Marchal, Shil Patel, Sachin Velankar, Kirk C. Hansen, Kevin McGrath, Stephen F. Badylak
Abstract
= 2) did not regress. The results suggest that in vivo alteration of the microenvironment with a site-appropriate, mucoadhesive ECM hydrogel can mitigate the inflammatory and metaplastic response in a dog model of BE.
Topics & Concepts
Extracellular matrixMetaplasiaEpitheliumBasement membranePathologyEsophagusIntestinal metaplasiaCancer researchChemistryMedicineBiologyCell biologyDysplasiaInternal medicineEsophageal and GI PathologyTissue Engineering and Regenerative MedicineEsophageal Cancer Research and Treatment