Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury
Yuanyuan Cheng, Liangkai Cheng, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang, Zhongqiu Liu
Abstract
Our results indicated that PBA might be a new Nrf2 activator that covalently binds to two critical domains of Keap1, and shows cardioprotective activities against ischemia-reperfusion injury.
Topics & Concepts
KEAP1ChemistryOxidative stressIn vivoInflammasomeUbiquitinCysteineUbiquitin ligasePharmacologyDocking (animal)BiochemistryMedicineEnzymeBiologyReceptorTranscription factorNursingGeneBiotechnologyGenomics, phytochemicals, and oxidative stressInflammasome and immune disordersCardiovascular, Neuropeptides, and Oxidative Stress Research