One-step<i>in situ</i>deposition of phytic acid–metal coordination complexes for combined<i>Porphyromonas gingivalis</i>infection prevention and osteogenic induction
Ning Gan, Wei Qin, Chunlei Zhang, Ting Jiao
Abstract
. The abundant phosphate groups greatly increased the surface hydrophilicity, promoted the early adhesion of proteins, improved the proliferation of bone marrow mesenchymal stem cells, and finally achieved an enhanced osteogenic activity. In addition, the phosphate groups of PA also facilitated the deposition of hydroxyapatite by providing reaction sites to chelate with calcium ions. These findings evaluate the anti-bacterial and osteogenic potentials of PA-metal coordination complexes, and clarify the feasibility for surface modification of dental implants.
Topics & Concepts
Porphyromonas gingivalisPhytic acidIn situMetalMaterials scienceMicrobiologyChemistryMedicinePeriodontitisBiochemistryBiologyMetallurgyInternal medicineOrganic chemistryPhytase and its ApplicationsOral microbiology and periodontitis researchFolate and B Vitamins Research