H<sub>2</sub>O<sub>2</sub>-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy
Yang Wang, Xufeng Liang, Jian An, Jia Pu, Yujia Meng, Yiqiao Bai, Wenqiang Yu, Yunhan Gao, Tingting Chen, Yong Yao
Abstract
-responsive carbon monoxide nanogenerator was designed by effectively encapsulating a manganese carbonyl prodrug into porphyrinic covalent organic polymers for realizing the combined CO gas and photodynamic therapy under near infrared light irradiation.
Topics & Concepts
Photodynamic therapyChemistryCovalent bondPolymerPhotochemistryPorphyrinCombinatorial chemistryOrganic chemistryHeme Oxygenase-1 and Carbon MonoxideNanoplatforms for cancer theranosticsCovalent Organic Framework Applications