Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against <i>Mycobacterium tuberculosis</i>
Lei Li, Logan W. MacIntyre, Thahmina Ali, Riccardo Russo, Bimal Koirala, Yözen Hernández, Sean F. Brady
Abstract
growth in murine macrophages and increases the activities of ClpC1 ATPase and the associated ClpC1/P1/P2 protease complex, thus causing cell death by uncontrolled protein degradation.
Topics & Concepts
Nonribosomal peptideMycobacterium tuberculosisProteaseTuberculosisBiologyMycobacteriumMicrobiologyBacteriaAntibioticsGeneVirologyBiochemistryBiosynthesisEnzymeGeneticsMedicinePathologyMicrobial Natural Products and BiosynthesisBiochemical and Structural CharacterizationPeptidase Inhibition and Analysis