Chiral Hypervalent Iodine Catalysis Enables an Unusual Regiodivergent Intermolecular Olefin Aminooxygenation
Fan Wu, Navdeep Kaur, Nur‐E Alom, Wei Li
Abstract
A novel iodide-catalyzed intermolecular aminooxygenation strategy is described here. Amide is used as the O- and N- source to probe for regiocontrol strategies. Notably, simple additives can be selectively introduced to achieve regiodivergent oxyamination processes for electronically activated alkenes while being regio-complementary for unactivated alkenes. Our preliminary data demonstrates that this regiocontrol strategy based on nucleophile can also be applied in asymmetric processes using chiral hypervalent iodine catalysis.
Topics & Concepts
Hypervalent moleculeIntermolecular forceChemistryCatalysisIodineOlefin fiberEnantioselective synthesisRegioselectivityIodideCombinatorial chemistryNucleophileOrganic chemistryAmideComputational chemistryStereochemistryMoleculeOxidative Organic Chemistry ReactionsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods