Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization
Xiaobin Zhang, Xiaolin Sun, Guo Chen, Jianan Li, Guobiao Liang
Abstract
The cancer-associated fibroblast (CAF)-related gene insulin-like growth factor binding protein-2 (IGFBP2) is highly expressed in gliomas and is associated with poor prognosis. CAF-related gene IGFBP2 promotes glioma progression by inducing polarization of M2 macrophages. This study provides a new basis for an in-depth investigation of the functional mechanisms of the glioma tumor microenvironment and the search for key genes involved in immune regulation in CAF.
Topics & Concepts
GliomaCancer researchImmune systemMacrophage polarizationGeneTumor microenvironmentBiologyTumor progressionFibroblastImmunologyPhenotypeCell cultureGeneticsCancer, Hypoxia, and MetabolismImmune cells in cancerGlioma Diagnosis and Treatment