Alginate/chitosan-based hydrogel loaded with gene vectors to deliver polydeoxyribonucleotide for effective wound healing
Xiaodong Jing, Yanzhen Sun, Yang Liu, Xiaoli Ma, Hao Hu
Abstract
nanoparticle (PCNP) to improve the delivery efficiency of PDRN. PCNPs were encapsulated in an alginate/chitosan-based hydrogel (Gel@PCNPs). The prepared hydrogel has plasticity and is suitable for various irregular wounds. The released gene carrier, PCNP, can be effectively taken up by skin fibroblasts. Under the action of PDRN, the wound healing rate has been confirmed to be significantly accelerated. We believe that this polysaccharide-based hydrogel loaded with PDRN vectors is a promising wound dressing.
Topics & Concepts
ChitosanSelf-healing hydrogelsWound healingChemistryGenetic enhancementGene transferBiomedical engineeringGenePolymer chemistrySurgeryMedicineBiochemistryRNA Interference and Gene DeliveryWound Healing and TreatmentsElectrospun Nanofibers in Biomedical Applications